Technology administration active substance in the ointment base

  • V. V. Trochimchuk Shupyk National Medical Academy of Post-Graduate Education, Кyiv
  • V. V. Shmatenko Ukrainian Military Medical Academy, Кyiv
  • V. O. Tarasenko Ukrainian Military Medical Academy, Кyiv
  • A. O. Drozdova Shupyk National Medical Academy of Post-Graduate Education, Кyiv
DOI: https://doi.org/10.32352/0367-3057.1.15.02
Keywords: ofloxacin, nimesulide, lidocaine, antimicrobial activity, the test culture, culture medium, ointment

Abstract

The problem of expanding the range of medicines that are used for the topical treatment of wound process, remains an important challenge for practical military medicine. In this aspect, there are topical ointments combining development for use in the first phase of wound process, which has a complex influence on the pathological processes and exhibits antibacterial, anti-inflammatory and local anesthetic activity.

The aim of the study was substantiation of technological route of administration of the active pharmaceutical ingredients in the ointment base, depending on the antimicrobial activity of model compositions.

The study included a model sample of ointment bases, cooked on a hydrophilic carrier containing active pharmaceutical ingredients – ofloxacin, nimesulide and lidocaine.

Microbiological studies were performed by difution on solid agar medium, which is based on the ability of substances to inhibit the growth antibakterial microorganisms.

Comparative analysis of experimental studies showed that the samples of ointments, which are based whith the active pharmaceutical ingredients ofloxacin, nimesulide and lidocaine was injected as a solution in DMSO showed the highest antimicrobial activity.

As a result of study on the antimicrobial activity of ointments model samples determined that the optimal method of administering the basis AFI – ofloxacin, nimesulide and lidocaine – a method of administering them in the form of a solution in DMSO.

References

1. Blatun L. A. Local medication wound treatment // Surgery. – 2011. – N 4. – P. 51–59.
2.Pertsev I. M., Kotenko A. M., Chueshov O. V., Khalaeva E. L. Pharmaceutical and biological aspects of ointments. – Kharkiv: Publishing house NFUU "Golden Pages", 2003. – 288 p.
3. Clinic of microbiological antimicrobial chemotherapy. – 2004. – V. 6, N 4.
4. Study of specific activity of antimicrobial drugs (Method of recommendation). – K., 2004. – 39 p.
5. State Pharmacopoeia of Ukraine. – Kharkiv: RIREG, 2001. – 556 p.
6. Determination of the sensitivity of microorganisms to antibacterial preparations (Method of guidance of MUK 4.2.1890-04). – K., 2004. – P. 314–316.
7. Pat. 70983 Ukraine MPKA61K 9/06 (2006.01), A61K 31/00, A61P 17/00. Pharmaceutical composition Oplimin in the form of an ointment with anti-inflammatory, antimicrobial, analgesic and reparative action / V. V. Shmatenko, V. V.Trohymchuk, V. O. Tarasenko. – N u201315497, Declared. March 30, 2013; 04. 04. 2014, Bul. N 8
8. European Pharmacopeia. – 4th ed. – Strasbourg: Council of Europe, 2003 – 2416 p.
Published
2019-02-12
How to Cite
Trochimchuk, V. V., Shmatenko, V. V., Tarasenko, V. O., & Drozdova, A. O. (2019). Technology administration active substance in the ointment base. Farmatsevtychnyi Zhurnal, (1), 38-42. https://doi.org/10.32352/0367-3057.1.15.02
Issue
No. 1 (2015): Farmatsevtychnyi zhurnal
Section
Pharmaceutical technology
Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.