Antimicrobial and antifungal properties of 4-((R-iden)amino)-5-(thiophen-2-ylmethyl)-4H-1,2,4-triazole-3-thiol

  • A. A. Safonov Zaporizhzhia State Medical University
  • Т. V. Panasenko Zaporizhzhia State Medical University
  • E. G. Knysh Zaporizhzhia State Medical University
  • N. M. Polishchuk Zaporizhzhia State Medical University
Keywords: antimicrobial and antifungal action, 4 - ((R-iden) amino) -5- (thiophen-2-ylmethyl) -4H-1,2,4-triazole-3-thiol, 1,2,4-triazole


For creating a new biologically active compounds are using a system on which already exist medications. One such system is the core of 1,2,4-triazole.

The aim of our work was to study the antimicrobial and antifungal activity new 4-((R-iden)amino)-5-(thiophen-2-ylmethyl)-4H-1,2,4-triazole-3-thiols. The study was conducted according to the method of serial dilutions.

As a result of studies new synthesized 4-((R-idene)amino)-5-(thiophene-2-ilmetyl)-4H-1,2,4-triazoles-3-thiols exhibit antimicrobial and antifungal activity.

The most active compound that exhibits antimicrobial activity against Staphylococcus aureus is 4-((1-(phenyl)ethylidene)amino)-5-(thiophene-2-ilmetyl)-4H-1,2,4-triazoles-3-thiol and 4-((3-nitrobenzylidene)amino)-5-(thiophene-2-ilmetyl)-4H-1,2,4-triazoles-3-thiol, 4-((4-fluorbenzylidene)amino)-5-(thiophene-2-ilmetyl)-4H-1,2,4-triazoles-3-thiol exhibit antifungal activity level of the comparator fluconazole, compound III, VI exceed its performance.


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How to Cite
Safonov, A. A., PanasenkoТ. V., Knysh, E. G., & Polishchuk, N. M. (2019). Antimicrobial and antifungal properties of 4-((R-iden)amino)-5-(thiophen-2-ylmethyl)-4H-1,2,4-triazole-3-thiol. Farmatsevtychnyi Zhurnal, (2), 96-99.
General and Clinical Pharmacology

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