Synthesis, physico-chemical properties of 3-thio and 3-thio -4-amino derivatives of 1,2,4-triazole
Keywords:
3-thio and 3-thio-4-amino derivatives of 1,2,4-triazole, physico-chemical properties, synthesis
Abstract
Modern medicine and pharmacy has at its disposal highly efficient synthetic drugs. Large extent of these drugs accounted for derivatives of 1,2,4-triazole.
The purpose of the work was an attempt to summarize the literature in recent years related to the methods of synthesis and study of physico-chemical properties 3-thio- and 3-thio-4-amino derivatives of 1,2,4-triazole.
Studies national scientists in recent years indicates prospects of the search in this direction, since this class of organic compounds is interest not only to scientists pharmaceutical, medical and veterinary field, but also among researchers of engineering, metallurgical and agricultural areas. 1,2,4-triazole derivatives are also widely used in practice for optical materials, photosensitizers are used as coloring agents, antioxidants, additives for fuels and oils, some of which are widely used as corrosion inhibitors for controlling various pests in agriculture. In addition, 1,2,4-triazole derivatives belong to the class low toxic or essentially non-toxic substances.
The presence of a growing number of publications about methods of synthesis, reactions, physico-chemical and biological properties of 1,2,4-triazole, inspires scientists around the world search for perspective molecules of substituted 1,2,4-triazole. It should be noted that in spite of a sufficient amount of information about the derivatives of 1,2,4-triazole, some issues related to the generalization of data in the literature synthesis presented insufficient.
References
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21. Benoít Rigo, Daniel Couturier. Studies are pyrrolidinones. Synthesis of 5- (5-Oxo-2-pyrrolidinyl) -1,2,4-triazole-3-thione derivatives // Chem. Heterocyclic Compounds. - 1989. - V. 26, N 6. - P. 1723-1727.
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24. Almasirat Ali, Vousooghi Nasim, Tabatabai Sayy Abbas, Kebriaeezadeh Shafiee Abbas. Synthesis, anticonvulsant and muscle relaxant activities of substituted 1,3,4-oxadiazole, 1,3,4-thiadiazole and 1,2,4-triazole // Acta chim. Sloven - 2007. - P. 54, N 2. - P. 317-324.
25. Tozkoparan B., Aytaç S. P., Gürsoy Ş., Aktay G. Design and synthesis of some thiazolotriazolyl esters as anti-inflammatory and analgesic agents // Mol. Chem Res - 2012. - V. 21, Issue 2. - P. 192-201.
26. Linghua Cao, Lin Zhang, Pengyuan Cui. Synthesis of 3- (3-alkyl-5-thioxo-1H-4,5-dihydro-1,2,4-triazol-4-yl) aminocarbonylchromones // Chem. Heterocyclic Compounds. - 2004. - V. 40, N 5. - P. 635-640.
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28. Bon VV, Orysyk SI, Pekhnyo VI [Cu3 (C11H12N3OS) 3 (C11H10N3OS)] SO4 • 3H2O, a Trinuclear Heteroleptic Copper (II) Complex with N-Allyl-N'-Salicylidenethiosemicarbazone and its Cyclization Product: Synthesis and X- Ray Diffraction Study // Russian J. Coordination Chem. - 2011. - V. 37, N 2. - P. 149-152.
29. Almasirad Ali, Vousooghi Nasim, Tabatabai Sayyed Abbas et al. Synthesis, anticolvulsant and muscle relaxant activities of substituted 1,3,4-oxadiazole, 1,3,4-thiadiazole and 1,2,4-triazole // Acta chim. Sloven - 2007. - P. 54, N 2. - P. 317-324.
30. Modzelevska-Banachiewicz B., Michalec B., Kamińska T. et al. Synthesis and biological activity of (Z) and (E) isomers of 3- (3,4-diaryl-1,2,4-triazole-5-yl) prop-2-enoic acid // Monatsh. Chem - 2009. - V. 140, N 4. - P. 439-444.
31. Gobis K., Fox H., Francuz J. et al. Studies are pyrazine derivatives. XLVI The syncesis of novel pyridine derivatives with N '- (pirazine-2-carbonyl) -hydrazinecarbodithionic acid methyl ester use // Phosph., Sulfur and Silicon and Relat. Elem - 2006. - Vol. 181, No. 5. - P. 977-986.
32. Application 19528300 Germany, MKI6 C 07 D 249/12, A 01 N 43/653. 2-Phenylethylmercapto triazole / M.Jautelat, R.Tiemann, St. Dutzmarm et al. - No. 19528300.7; Declared 02. 08. 1995; Pubwished 06.02.2000.
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Published
2019-02-12
How to Cite
Parchenko, V. V. (2019). Synthesis, physico-chemical properties of 3-thio and 3-thio -4-amino derivatives of 1,2,4-triazole. Farmatsevtychnyi Zhurnal, (2), 28-44. https://doi.org/10.32352/0367-3057.2.15.01
Section
Synthesis and analysis of biologically active compounds
This work is licensed under a Creative Commons Attribution 4.0 International License.
