Antiseptic properties of aminoadamantane derivative

  • N. O. Vrynchanu SI «Institute of pharmacology and toxicology of NAMS of Ukraine», Kyiv
  • V. L. Makitruk PJSC SIC «Borshchahivskiy chemical-pharmaceutical plant», Kyiv
  • A. S. Shalamay PJSC SIC «Borshchahivskiy chemical-pharmaceutical plant», Kyiv
  • M. L. Dronova SI «Institute of pharmacology and toxicology of NAMS of Ukraine», Kyiv
  • D. M. Dudikova SI «Institute of pharmacology and toxicology of NAMS of Ukraine», Kyiv
  • Z. S. Suvorova SI «Institute of pharmacology and toxicology of NAMS of Ukraine», Kyiv
  • A. O. Sharova SI «Institute of pharmacology and toxicology of NAMS of Ukraine», Kyiv
Keywords: adamantane derivatives, antiseptic properties, fungicidal activity, bactericidal activity

Abstract

Development of microbial resistance to current antimicrobial drugs created a critical need of the new antiseptics. The object of our study was phenyladamantane derivative (4-(adamantyl-1)-1-(1-aminobutyl)benzol, AM-166). The aim of the presented study was to investigate the specific activity of 4% AM-166 solution in isopropanol and 5% AM-166 solution in 76% ethanol (manufactured by PJSC SIC «Borshchahivskiy CPP») against the wide spectrum of bacteria and fungi, and effective concentrations and exposition time determination. Desinfectant/antiseptic activity was evaluated by quantitative suspension method with subsequent neutralization.

Our results showed that both solutions exhibited similar activity against gram-positive and gram-negative bacteria as well as against yeasts. Antibacterial and antifungal action was demonstrated for all investigated concentrations (initial solution, 5-fold and 10-fold dilutions), observed effect was maintained throughout the whole observation period (from 5 to 30 min).

Tested solutions in initial concentrations demonstrated fungicidal activity against A. niger. 5-fold dilution of 5% AM-166 solution in 76% ethanol was more effective than 5-fold dilution of 4% AM-166 solution in isopropanol. 10-fold dilutions of both solutions were ineffective against A. niger. The data obtained suggest the prospects of adamantane derivatives for the development of novel antiseptics.

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Published
2018-08-14
How to Cite
Vrynchanu, N. O., Makitruk, V. L., Shalamay, A. S., Dronova, M. L., Dudikova, D. M., Suvorova, Z. S., & Sharova, A. O. (2018). Antiseptic properties of aminoadamantane derivative. Farmatsevtychnyi Zhurnal, (5-6), 49-54. https://doi.org/10.32352/0367-3057.5-6.17.06

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