The study of structural-mechanical and physico-chemical properties of the samples of a gel base to create a drug for treating acne
High incidence of acne and comedogenous dermatoses (rosacea, demodecosis) among adolescents, people of young and middle age and elderly people indicates a major medical and social importance of this problem. Therefore, there is a need to develop new domestic highly effective drugs with the multitargeted action. It has been found experimentally that the combination of the standardized substance of the propolis phenolic hydrophobic drug (PPHD) with azelaic acid on a gel base provides anti-inflammatory, antimicrobial, immune-stimulating and wound healing effect of the drug.
The aim of the work was to study structural-mechanical and physico-chemical properties of the samples of a gel base to create a drug in the form of a gel under conditional name «Propolis» for treating acne.
The objects of the rheological studies were 1.5% samples of the gel prepared on the basis of Carbopol 934 with different concentrations of propylene glycol (PG) and polyethylene oxide-400 (PEO-400) and their combinations, «Propolis» gel with the content of PPHD (2%) and the reference drug – «Skinoren» gel chosen for conducting pharmacological, microbiological and structural-mechanical studies.
As a result, the regularities of changes in the structural viscosity on the type of the solvent for PPHD (PG, PEO-400) and its concentration, as well as their combinations have been studied. It has been found that the combination of propylene glycol and PEO-400 promotes the structural viscosity increase in the total concentration than if these substances are taken separately in the same concentrations.
The results of the derivatographic research of individual substances of azelaic acid and PPHD, as well as «Propolis» gel are presented. They indicate the absence of the chemical interaction between the components of the drug and allow to carry out the technological process while heating since the change in the sample weight of the gel associated with its destruction occurs at the temperature of 103 оС and above.
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