Effect of different diluent’s type on trimetazidine dihydrochloride release from matrix tablets

  • V. V. Mohylyuk Shupyk National Medical Academy of Post-graduate Education, Kyiv
  • L. L. Davtian Shupyk National Medical Academy of Post-graduate Education, Kyiv
Keywords: matrix tablets, Ethocel, Kollidon SR, Methocel K, Avicel PH-101, Emcompress, Neosorb P100T


Oral matrix tablets are the modern dosage forms using which could be achieved desirable in vitro release kinetics of active pharmaceutical ingredient (API) and correspondent in vivo concentration level. That’s why the study of factors that affect in vitro dissolution release of API is an actual task and the affect of diluents type is one of these factors.

Particle size distribution measurement by the laser scattering method, tablet manufacturing using direct compression method, dissolution test and matrix tablets structure evaluation by optical microscopy were used for experiment.

Faster API release from Ethocel 10, Kollidon SR and Methocel K4M matrix tablets with sorbitol than Emcompress and Avicel PH-101 was established. During determination of Emcompress and Avicel PH-101 effect on release kinetics from matrix tablets with different matrix formers were established that release was faster using: Avicel PH-101 in insoluble unswellable matrix of Ethocel 10; Emcompress in insoluble swellable matrix of Kollidon SR; Avicel PH-101 in soluble swellable matrix of Methocel K4М. It was established that trimetazidine dihydrochloride release kinetics from matrix tablets with Ethocel 10, Kollidon SR and Methocel K4M and Emcompress diluent was higher in pH 1 medium than in pH 6,8 which is consistent with pH-dependent Emcompress solubility.


1. Wesselingh J. A. Controlling diffusion // J. Controlled Release. - 1993. - Vol. 24. - P. 47-60.

2. Khan G. M., Zhu J.-B. Evaluation of Ethocel Premium Ethyl Cellulose Ether Derivatives with Different Molecular Weights as Controlled-release Matrix Formulating Functional Polymer for ibuprofen // Asian Network for Sci Information. - 2001. - V. 1, N 6. - P. 361-367.

3. Lapidus H., Lordi N. G. Drug Release from Compressed Hydrophilic Matrices // J. Pharm. Sci - 1968. - V. 57, N 8. - P. 1292-1301.

4. Maderuelo C., Zarzuelo A., J. Lanao M. Critical factors in the release of drugs from sustained release hydrophilic matrices // J. Controlled Release. - 2011. - V. 154. - P. 2-19.

5. Jamzad S., Tutunji L., Fassihi R. Analysis of macromolecular changes and drug release from hydrophilic matrix systems // Int. J. Pharm. - 2005. - Vol. 292. - P. 75-85.

6. Tukaram B. N., Rajagoopalan IV, Shartchandra PS S. The effects of lactose, microcrystalline cellulose and dicalcium phosphate on swelling and erosion of a compressed HPMC matrix tablet: Texture Analyzer // Iranian J. Pharm. Research - 2010. - V. 9, N 4. - P. 349-358.

7. Levina M., Rajabi-Siahboomi, AR. The Influence of Excipients on drug release from hydroxypropyl methylcellulose matrices // J. Pharm. Sci - 2004. - V. 93, N 11. - P. 2746-2754.

8. Holgado M. A. et al. Influence of the diluents and the manufacturing method is the in vitro dissolution of carteolol hydrochloride matrix tablets // Int. J. Pharm. - 1995. - V. 118. - P. 151-160.

9. Lotfipour F. et al. The effect of hydrophilic and lipophilic polymers and fillers on the release rate of atenolol from the HPMC matrix // Il Farmaco. - 2004. - V. 59. - P. 819-825.

10. Espinoza-Ramos R., Villafuerte-Robles L. Influence of admixed lactose on pelanserin hydrochloride release from hydroxypropyl methylcellulose matrix tablets // Pharm. Acta Helvetiae. - 1999. - V. 74. - P. 65-71.

11. Mamani PL, Ruiz-Caro R., Veiga MD Matrix tablets: The effect of hydroxypropyl methylcellulose / anhydrous dibasic calcium phosphate ratio on the release rate of a water-soluble drug through the gastrointestinal tract I. In vitro assay // AAPS Pharm . Sci Tech - 2012. - V. 14, N 4. - P. 1073-1083.
How to Cite
Mohylyuk, V. V., & Davtian, L. L. (2018). Effect of different diluent’s type on trimetazidine dihydrochloride release from matrix tablets. Farmatsevtychnyi Zhurnal, (4), 16-23. Retrieved from https://pharmj.org.ua/index.php/journal/article/view/196
Pharmaceutical technology