Effect of different diluent’s type on trimetazidine dihydrochloride release from matrix tablets
Abstract
Oral matrix tablets are the modern dosage forms using which could be achieved desirable in vitro release kinetics of active pharmaceutical ingredient (API) and correspondent in vivo concentration level. That’s why the study of factors that affect in vitro dissolution release of API is an actual task and the affect of diluents type is one of these factors.
Particle size distribution measurement by the laser scattering method, tablet manufacturing using direct compression method, dissolution test and matrix tablets structure evaluation by optical microscopy were used for experiment.
Faster API release from Ethocel 10, Kollidon SR and Methocel K4M matrix tablets with sorbitol than Emcompress and Avicel PH-101 was established. During determination of Emcompress and Avicel PH-101 effect on release kinetics from matrix tablets with different matrix formers were established that release was faster using: Avicel PH-101 in insoluble unswellable matrix of Ethocel 10; Emcompress in insoluble swellable matrix of Kollidon SR; Avicel PH-101 in soluble swellable matrix of Methocel K4М. It was established that trimetazidine dihydrochloride release kinetics from matrix tablets with Ethocel 10, Kollidon SR and Methocel K4M and Emcompress diluent was higher in pH 1 medium than in pH 6,8 which is consistent with pH-dependent Emcompress solubility.
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