Hypoglycemic activity of Citrullus colocynthis (L.) Shrad. dry extract

  • G. Lamazian Bogomolets National Medical University, Kyiv
Keywords: diabetes mellitus, phytotherapy in diabetes, alloxan diabetes mellitus, Citrullus colocynthis (L.) Shrad., hypoglycemic effect


Phytotherapyof diabetes mellitus has several advantages over his chemotherapy: a wide range of biologically active substances, complex and physiological effects on the organism, low toxicity. That is why the search for ever new and more effective herbal remedies for the treatment of this disease is an urgent problem of medicine and pharmacy.

The aim of investigations was to study the hypoglycemic activity of medicinal plant Citrullus colocynthis (L.) Shrad. in the acute experiment on the model of alloxan diabetes in rats. The object of study is a dry extract of Citrullus colocynthis (L.) Shrad.

Daily for seven days animals with experimental diabetes was orally administered herbal extract in dose of 200 mg / kg. Glucose levels in the blood of animals were recordedon the third and seventh day. At the same time blood glucose level wasmeasured inanimal groups of diabetic and non-diabetic controls.

Studies have shown that the dry extract of Citrullus colocynthis (L.) Shrad. causes a statistically significant decrease of blood glucose in rats with alloxan diabetes. Thus its hypoglycemic activity was more pronounced on the seventh day of the experiment and was 40.3%.


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How to Cite
Lamazian, G. (2018). Hypoglycemic activity of Citrullus colocynthis (L.) Shrad. dry extract. Farmatsevtychnyi Zhurnal, (5), 90-94. Retrieved from https://pharmj.org.ua/index.php/journal/article/view/191
General and Clinical Pharmacology