Study of the acute toxicity of the praziquantel using different routs of administration
Patients with similar to acne dermatosis have more strongly pronounced clinical symptoms and significant increase of relapses rate in case of the demodicosis presence. Praziquantel is an antiparasitic substance with activity regarding to flukes and cestodes. Investigations carried out by the domestic scientists exposed also a presence of the antidemodicosic effect.
In Ukraine praziquantel is registered in the form of the oral tablets long using of which provokes gastrointestinal side effects. In view of this fact usage of alternative praziquantel routs of administration draws interest.
The aim of this work is study of the acute toxicity of the praziquantel using intraperitoneal, oral, rectal and topical administration.
Investigations of the toxicity were carried out according to the order of preclinical study and data examination of the preclinical study of drugs.
It was established that praziquantel intraperitoneal (LD50 = 564 mg/kg) and intragastric (LD50 = 1 030 mg/kg) administration in white rats by the extent of toxicity is a slightly dangerous substance (3 toxicity class). Study of the acute toxicity of the model semisolid application dosage forms in subtoxic dose for external administration showed that single applying of the external ointment and rectal suppository with this active substance in the maximum allowable volume doesn’t lead to the laboratory animal’s death and doesn’t negative influence on the examining parameters of their homeostasis. It is determined that praziquantel dosage forms for the external and rectal administration less toxic than oral tablets and are practically nontoxic substances.
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