Studies of phthalates pigeon scabious (Scabiosa columbaria L.)

  • R. B. Vinnitska Ivano-Frankivsk National Medical University
Keywords: Scabiosa columbaria L., phthalates, gas chromatography-mass-spectrometry


Scabiosa columbaria L. (Pigeon scabious) – a perennial herb of the Teasel family (Dipsacaceae), which occurs in the Carpathian region. The plant is used in folk medicine as a antitussive remedy for acute respiratory diseases and in the treatment of scabs, from which is said to have happened its Latin name. Information about the chemical composition of plants is quite limited, although it is known that it contains tannins, saponins and bitter constituens.

The aim of its study is investigation of chemical composition aerial part of plant and identify substances that may have antiparasitic and repellent properties.

For this purpose herbs were collected during flowering, dried, milled, defatted and extracted with ethanol. After distilling off the ethanol, aqueous residue was extracted with ethyl acetate. The resulting residue was separated on a polyamide column. Qualitative and quantitative composition of the fractions were examined by gas chromatography-mass-spectrometry.

The ethyl acetate extract on a polyamide column was separated on the three fractions, which were different solubility in ethanol. Using gas chromatography-mass-spectrometry was found that fractions of the ethyl acetate extract scabiosa pigeon predominate esters of higher fatty acids (such as palmitic) and phthalic acid. As major components identified diisooctylphtalate, bis-(ethylhexyl)phthalate and dibutylphthalate. In particular, in the fractions N 3 the two ethers of phthalic acid were about 90% (dibutylphthalate and bis-(ethylhexyl)phthalate) of the total weight of fraction. In fractions N 1 and N 2 phthalate content was somewhat lower – 72.18% and 34.54%, respectively.

Based on the expressed anti-parasitic action of these substances can be assumed that the data of folk medicine about anti-parasitic action scabiosa pigeon are not motiveless, but require further testing.


1. Katayon Javidnia, Ramin Miri, Azita Javidnia. Constituents of essential oil of Scabiosa flavida from Iran // Chemistry of Natural Compounds. - 2006. - Vol. 42, N 5. - P. 529-530.
2. Garaev E.A., Movsumov I.S., Isaev M.I., Flavonoids and Oleanolic Acid from Scabiosa caucasica // Ibid. - 2008. - V. 44, N 4. - P. 520-521.
3. Tsivinska M.V., Panchak L.V., Stoika R.S., Antonyuk V.O. Isolation, characteristics, and antioxidant activity of low volecular compounds of fruit bodies. Lactarius pergamenus (Fr.) Fr mushrooms // J. Advances in Biol. - 2015 - V. 6, N 3. - P. 1023-1035.
4. Jill E. Maddison, Stephen W. Page. Small animal clinical pharmacology. - New York: 2nd edition, 2008. - 574 p.
5. Adams W. J., Biddinger G. R., Robillard K. A., Gorsuch J. W. A summary of the acute toxicity of 14 phthalate esters to representative aquatic organisms // Environmental Toxic. Chem - 1995. - V. 14. - P. 1569-1574.
6. Mikula P., Svobodová Z., Smutná M. Phthalates: toxicology and food safety - a review // Czech. J. Food Sci. - 2005. - N 23. - P. 217-223.
7. Akimova L. N., Senkevich G. G., Dunets T. G., Kurchenko V. P. The influence of essential oils and phthalates on the viability of the cercariae of the Schistosomatidae family and the creation of protective agents against them on the basis of the cercariosis // Trudy Beloruss. state un-that - 2008. - T. 3, Ch. 1. - P. 1-22.
How to Cite
Vinnitska, R. B. (2018). Studies of phthalates pigeon scabious (Scabiosa columbaria L.). Farmatsevtychnyi Zhurnal, (1), 59-63. Retrieved from
Pharmacological, phytochemical research