Tail-flick-est – aspects use in pharmacological researches

  • T. V. Kava Bogomolets National Medical University, Kyiv
  • O. E. Yadlovskiy Bogomolets National Medical University, Kyiv
Keywords: Tail-Flick, nociception, analgesics, pharmacological research

Abstract

The adequate assessment of anti-nociceptive activity is important. This is necessary for development of new analgesics that exceed effectiveness and/or safety of existing analgesics, fundamental research, study specifics pharmacodynamics of known analgesics.

Рurpose of work is scientific and methodical analyze approaches to study of antinociceptive activity with Tail-flick test.

The study was carried out using databases on the Internet using science-based databases: PubMed, Medline, Europe PMC, FDA, EMA, Google Scholar. Methods of approach to planning, conducting an experiment, interpretation of the received data were analyzed. It were use retrospective, logical and system-analytical research methods.

It has analyzed the level scientific physiological, pharmacological, and experimental data of anesthetic activity evaluation of Tail-flick-test. The method has several advantages, among them: simplicity, lack special skills from experimenter, effectiveness for screening opioid and other analgesics, the accuracy of the results of the experiment and moderate time consumption of experiment. But method has some disadvantages, namely: adaptation animals to nociceptive irritation (re-stimulation, especially when reducing the intervals between measurements; increase intensity radiation). Tail-flick-test did not reveal appropriate efficacy study anti-nociceptive activity of opioid receptor antagonist- agonists.

Thus, the Tail-flick test is one of the most adequate methods for Tail-flick-test is informative to study of the opioid component of analgesics. The accuracy and adequacy of the experimental data depends on the characteristics of the experiment setting and the rules for conducting the research.

References

1. Yesin R. G., Yesin O. R., Akhmadeyeva G. D., Salikhova G. V. Bol' v spine. – M.: Meditsina, 2010. – 272 s.

2. Dieleman J. P., Kerklaan J., Huygen F. J. P. M. et al. Incidence rates and treatment of neuropathic pain conditions in the general population // Pain. – 2008. – V. 137, N 3. – P. 681–688.

3. Hempenstall K., Nurmikko T. J., Johnson R. W. et.al. Which Treatment for Postherpetic Neuralgia? // PloS Medicine. – 2005. – V. 2, N 7. – P. 238.

4. Goodman A., Gilman L. The pharmacological basis of Therapeutic (9th ed.). – New York: McGraw-Hill., 1996. – Ch. 27. – P. 836–932.

5. Kanner R. Sekrety lecheniya boli. Per. s angl. – M.: «Izdatel'stvo BINOM», 2006. – 400 s.

6. Recognition and Alleviation of Pain in Laboratory Animals. National Research Council (US) Committee on Recognition and Alleviation of Pain in Laboratory Animals. – Washington (DC): National Academies Press (US), 2009 [Electronic resource]. – Access mode: https://www.ncbi.nlm.nih.gov/books /NBK32655/

7. Sinclair J. G., Main C. D., Lo G. F. Spinal vs supraspinal actions of morphine on the rat tail-flick reflex // Pain. – 1988. – V. 33. – P. 357–362.

8. D’Amour F. E., Smith D. L. A method for determining loss of pain sensation // J. Pharmacol. Exp. Ther. – 1941. – V. 72, N 1. – P. 74–78.

9. Hardy J. D., Stoll A. M., Cunningham D. et al. Responses of the rat to thermal radiation // Am. J. Physiol. – 1957. – V. 189. – P. 1–5.

10. Hardy J. D., Wolff H. G., Goodell H. Studies on pain. A new method for measuring pain threshold: observation on spatial summation of pain // J. Clin. Invest. – 1940. – V. 19. – P. 649–657.

11. Le Bars D., Gozariu M., Cadden S. W. Animal Models of Nociception // Pharmacol. Rev. – 2001. – V. 53. – P. 597–652.

12. Gårdmark M., Höglund A. U., Hammarlund-Udenae M. Aspects on Tail-Flick, Hot-Plate and Electrical Stimulation Tests for Morphine Antinociception // Basic & Clinical Pharmacology & Toxicology. – 1998. – V. 83, N 6. – P. 252–258.

13. Raffa R. B., Friderichs E., Reimann W. et al. Opioid and nonopioid components independently contribute to the mechanism of action of tramadol, an «atypical» opioid analgesic // J. Pharmacol. Exp. Ther. – 1992. – V. 260. – P. 275–285.

14. Milind P., Monu Y. Laboratory models for screening analgesic // Inter. Res. J. Pharmacy. – 2013. – V. 4, N 1. – Р. 15–19.

15. Beran T., Vaculín Š., Franěk M. Comparison of two methods of tail flick latency measurement in rat // Bolest. – 2010. – V. 13, N 3. – P. 124–127.

16. Granat F. R., Saelens J. K. Effect of stimulus intensity on the potency of some analgetic agents // Arch. Int. Pharmacodyn. Ther. – 1973. – V. 205. – P. 52–60.

17. Kawakita K., Funakoshi M. A quantitative study on the tail flick test in the rat // Physiol. Behav. – 1987. – V. 39. – P. 235–240.

18. Ness T. J., Jones S. L., Gebhart G. F. Contribution of the site of heating to the variability in the latency of the rat tail flick reflex // Brain Res. – 1987. – V. 426. – P. 169–172.

19. Carstens E., Wilson C. Rat tail flick reflex: magnitude measurement of stimulus-response function, suppression by morphine and habituation // J. Neurophysiol. – 1993. – V. 70, N 2. – P. 630–639.

20. King T. E., Joynes R. L., Grau J. W. Tail-flick test: II. The role of supraspinal systems and avoidance learning // Behav. Neurosci. – 1997. – V. 111. – P. 754–767.

21. Vogel Gerhard H. Drug Discovery and Evaluation. Pharmacological Assays Second Completely Revised, Updated, and Enlarged Edition. Springer-Verlag Berlin Heidelberg, 2002. – 1026 р.

22. Kříž N., Yamamotová A., Tobiáš J., Rokyta R. Tail-Flick Latency and Self-Mutilation Following Unilateral Deafferentation in Rats // Physiol. Res. – 2006. – V. 55. – P. 213–220.

23. Danneman P. J., Kiristsy-Roy J. A., Morrow T. J., Casey K. L. Central delay of the laser-activated tail-flick reflex // Pain. – 1994. – V. 58. – P. 39–44.

24. Tjølsen A., Lund A., Berge O. G., Hole K. An improved method for tail-flick testing with adjustment for tail-skin temperature // J. Neurosci. Methods. – 1989. – V. 26, N 3. – P. 259–265.

25. Vogel Gerhard H. Drug Discovery and Evaluation. Pharmacological Assays Second Completely Revised, Updated, and Enlarged Edition. Springer-Verlag Berlin Heidelberg, 2002. – 1026 р.

26. © 2017 Harvard Apparatus [Electronic resource]. – Access mode: http://www.ugobasile.com/catalogue/category/pain_and_inflammation/product/37370_pla ntar_test__hargreaves_apparatus_.html

27. Plantar Test Apparatus (Hargreaves Method) and Tail Flick Test in 1 [Electronic resource]. – Access mode: https://www.iitcinc.com/Plantar_tailflick.html
Published
2018-08-14
How to Cite
Kava, T. V., & Yadlovskiy, O. E. (2018). Tail-flick-est – aspects use in pharmacological researches. Farmatsevtychnyi Zhurnal, (1-2), 61-67. https://doi.org/10.32352/0367-3057.1-2.18.07