Study of structural-mechanical properties for choosing the basis of pharmaceutical composition in ointment form

Keywords: cream base, the emulsion, the oil phase, emulsifiers, rheological studies, structural and mechanical properties


Rational treatment of wounds is a pressing problem of our time, especially during hostilities. Practice has shown that currently there is no universal method of local wound healing. Therefore, a differentiated approach to the development of drugs for the local treatment of the wound process is needed. Among the dosage forms for topical use, soft drugs are a convenient dosage form for topical use. Thanks to the excipients which are a part of soft medicines, it is possible to regulate release of active pharmaceutical ingredients that, in turn, provides medical action of drug. The technology of drug preparation, which includes the substantiation of the temperature regime of drug production, the study of their physico-chemical and structural-mechanical properties affects the therapeutic efficacy of the drug.

The aim of the work was to study the structural and mechanical properties of model samples for choosing the basis of the pharmaceutical composition in the form of an ointment.

The object of the study were model samples of bases made on the basis of oil/water emulsion and water/oil. Measurements of rheological parameters of ointment bases and their homogeneity were performed according to the methods of the State Pharmacopoeia of Ukraine (2.2.10 and SPU 1 in Annex I).

Studies of thermal stability and colloidal stability were performed according to DSTU 4765: 2007. Cosmetic creams. General technical conditions. [Effective from 2009-01-01]. Rheological studies of model samples of ointment bases immediately after their manufacture and their physicochemical properties (homogeneity, thermal stability and colloidal stability) both after fabrication and during 6 months of storage at room temperature. It is proved that all samples have elastic-plastic-viscous properties, thixotropy and ability to lubricate well, homogeneity and thermal and colloidal stability.

The study of the structural and mechanical properties of model bases has shown that these samples of bases can be used as carriers of drugs in the development of soft drugs.

The prospect of this study is to study the osmotic properties of model samples in order to choose the basis that the medical and biological requirements will meet a certain phase of the wound process.


Brown H. L., Clayton A., Stephens P. The role of bacterial extracellular vesicles in chronic wound infections: Current knowledge and future challenges // Wound. Repair. Regen. – 2021. – V. 29, N 6. – P. 864–880.

Yenilmez M. I. Economic and Social Consequences of Population Aging the Dilemmas and Opportunities in the Twenty-First Century // Appl. Res. Quality Life. – 2015. – V. 10. – P. 735–752.

Bakker K., Apelqvist J., Schaper N. International Working Group on Diabetic Foot Editorial Board: Practical guidelines on the management and prevention of the diabetic foot 2011 // Diabetes Metab. Res. Rev. – 2012. – V. 28, Suppl. 1. – P. 225–231.

Hinchcliffe R. J., Andros G., Apelqvist J. et al. A systematic review of the effectiveness of revascularization of the ulcerated foot in patients with diabetes and peripheral arterial disease // Diabetes Metab. Res. Rev. – 2012. – V. 28, Suppl. 1. – P. 179–217.

Kovalenko O. M., Kovalenko A. O., Osadcha O. I. Vpliv ranovih pokrittiv na рН rani pri poverhnevih opikah // Klin. hirurgiya. – 2017. – № 2. – S. 28–30.

Tarasenko V. O., Davtian L. L., Voloh D. S. ta in. Visvitlennya okremih aspektiv zasobiv dlya likuvannya ran i ranovoyi infekciyi: istoriko-evolyucijnij pidhid // Fitoterapiya. Chasopis. – 2020 – № 2. – S. 43–47.

Tarasenko V. O., Davtyan L. L. Doslidzhennya fiziko-himichnih pokaznikiv kremu kompleksnoyi diyi dlya likuvannya ranovogo procesu poranenih vijskovosluzhbovciv // Akt. pitannya farmats. med. nauki ta praktiki. – 2018. – Т. 11, № 1/26. – S. 69–73.‐050

Vlasenko I. O., Davtian L. L. Active pharmaceutical ingredients in dermatological medicines of Ukrainian pharmaceutical market // Farmats. zhurn. – 2019. – № 1. – S. 9–19.

DSTU 4765:2007. Kremi kosmetichni. Zagalni tehnichni umovi. [Chinnij vid 2009-01-01]. Vid. ofic. – Kyiv: Derzhspozhivstandart Ukrayini, 2009. – 11 s.

How to Cite
Lutska, A. V., & Drozdova, A. O. (2022). Study of structural-mechanical properties for choosing the basis of pharmaceutical composition in ointment form. Farmatsevtychnyi Zhurnal, (3), 55-60.
Pharmaceutical technology