Analysis of the list and availability of medicines used for the treatment of atopic dermatitis in Ukraine

Keywords: dermatological diseases, atopic dermatitis, soft medicines, topical glucocorticosteroids, affordability, socio-economic affordability rate


The prevalence of atopic dermatitis (AD) is growing rapidly among the population, treatment protocols need to be reviewed, taking into account evidence-based medicine data and the introduction of new drugs and new forms in the country's market.

The aim of this study was to analyse the pharmaceutical component of treatment protocols in Ukraine, to conduct a comparative analysis of the list of medicines registered on the pharmaceutical market on 2022 (also in comparison with 2016). To determine the socio-economic affordability of TCGS for the treatment of AD at the regional level based on the availability ratio.

The objects of the study were topical glucocorticosteroids (TGCS) preparations according to the State Register of Medicines of Ukraine and the online resource «Apteka online». Analysis methods: information analysis, content analysis, marketing analysis, systematization and generalization.

The study of domestic protocols and the British recommendations for the treatment of AD showed that TGCS with evidence-based effectiveness are prescribed as first-line drugs, but domestic documents for the treatment of AD from 2016 need to be revised, taking into account actual evidence-based data. The results of this study of the TGCS assortment showed that as of February 1, 2022, there were 13 INN TGCS for the treatment of AD, corresponding to 104 trade names (TN) on the Ukrainian market. In 2016–2022, the assortment of TGKS increased in terms of TN by 10.6%, while imports grew by 16.1%, which indicates a positive trend in the segment. It was revealed that, compared with 2016, there is a negative trend of reducing the number of domestic producers of TCGS by 18.1%. Consequently, the share of imported TGCS preparations is 62.5%, which contributes to the growth of treatment costs.

An analysis of the assortment of TKGS according to the dosage form of the release shows that the main share among domestic drugs is ointments for, and for imported drugs – cream, but very small amounts in the form of lotions, emulsions. It was found that two medicines are low available: methylprednisolone aceponate, bemethasone, medicines have an average availability: mometasone furoate, bemethasone (lotion). It was revealed that the majority of domestically produced drugs are available to patients. It has been established that the range of TGCS in the treatment of AD is import-dependent, 5 INNs are not available in domestic production.

It has been substantiated that pharmacist should be aware of new TGCS, the features and duration of their administration in order to ensure good pharmaceutical care for the effective treatment of AD.


Otsinka dostupnosti osnovnykh likarskykh zasobiv dlia ambulatornoho likuvannia v Ukraini. – Kopenhahen: Yevropeiske rehionalne biuro VOOZ, 2021. – URL:

Matviychuk M. E., Hromovyk B. P. Research of assortment and price condition of the regional market of antidepressants for treatment of women in prenatal and postnatal periods // Farmats. zhurn. – 2021. – T. 76, № 4. – S. 55‒63.

Shmatenko O. P., Osodlo H. V., Vlasenko O. M., Plieshkova O. V. Analiz dostupnosti likarskykh zasobiv dlia likuvannia viiskovosluzhbovtsiv iz poranenniamy ta travmamy holovnoho mozku // Farmats. zhurn. – 2019. – № 1. – S. 43‒52.

Symonenko N. A., Podhaina M. V., Nemchenko A. S., Shpychak O. S. Analiz ekonomichnoi dostupnosti okremykh hrup kardiolohichnykh preparativ v Ukraini za 2016‒2020 roky // Farmats. chasopys. – 2021. – № 2. – S. 79‒86.

Zaliska O., Stasiv K., Maksymovych N., Hrynkiv Ya. The trends of assisted reproductive technologies and cost for ovarian stimulation protocols in Ukraine // Pharmacia. – 2020. – V. 67, N 4. – Р. 269‒276.

Kapur S., Watson W., Carr S. Atopic dermatitis // Allergy Asthma Clin. Immunol. – 2018. – V. 14, Suppl 2. – P. 52.

Plant A., Ardern-Jones M. R. Advances in atopic dermatitis // Clin. Med. (Lond). – 2021. – V. 21, N 3. – P. 177‒181.

Nakaz MOZ Ukrainy № 670 vid 04. 07. 2016 r. «Unifikovanyi klinichnyi protokol pervynnoi, vtorynnoi (spetsializovanoi), tretynnoi (vysokospetsializovanoi) medychnoi dopomohy atopichnyi dermatyt». – URL:

Adaptovana klinichna nastanova, zasnovana na dokazakh «Atopichnyi dermatyt» – 2016. – URL:

Laughter M. R., Maymone M. B. C., Mashayekhi S. et al. The global burden of atopic dermatitis: lessons from the Global Burden of Disease Study 1990-2017 // Br. J. Dermatol. – 2021. – V. 184, N 2 – P. 304‒309.

Kahn D., Iturriaga C., Bertran K. et al. Sleep quality in children with atopic dermatitis during flares and after treatment // Sleep Sci. – 2020. – V. 13, N 2. – P. 172‒175.

Zink A. G. S., Arents B., Fink-Wagner A. et al. Out-of-pocket Costs for Individuals with Atopic Eczema: A Cross-sectional Study in Nine European Countries // Acta Derm. Venereol. – 2019. – V. 99, N 3. – P. 263‒267.

NICE Atopic eczema in under 12s: diagnosis and management guideline. – URL:

Eichenfield L. F., Tom W. L., Berger T. G. et al. Guidelines of care for the management of atopic dermatitis: section 2. Management and treatment of atopic dermatitis with topical therapies // J. Am. Acad. Dermatol. – 2014. – V. 71, N 1. – P. 116‒132.

Axon E., Chalmers J. R., Santer M. et al. Safety of topical corticosteroids in atopic eczema: an umbrella review // BMJ Open. – 2021. – V. 11, N 7. – P. e046476.

Hlushchenko O. M., Chekhovska T. S. Monitorynh miakykh likarskykh zasobiv iz kortykosteroidamy dlia zastosuvannia v pediatrychnii praktytsi // Farmats. chasopys. – 2016. – № 2. – S. 43‒47.

Vlasenko I. O., Davtian L. L. Active pharmaceutical ingredients in dermatological medicines of Ukrainian pharmaceutical market // Farmats. zhurn. – 2019. – № 1. – S. 9–19.

Derzhavnyi reiestr likarskykh zasobiv Ukrainy. – URL: data zvernennia 01.02.2022

Koefitsiient adekvatnosti platospromozhnosti. Farmatsevtychna entsyklopediia Ukrainy. – URL: data zvernennia 01.02.2022

How to Cite
Zaliska, O. M., Maksymovych, N. M., Zabolotnya, Z. O., & Zalisky, B. M. (2022). Analysis of the list and availability of medicines used for the treatment of atopic dermatitis in Ukraine. Farmatsevtychnyi Zhurnal, (2), 25-37.
Management of pharmacy

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