Study of antibacterial activity of combined vaginal pessaries with fluconazole and amaranth oil

  • T. G. Yarnykh National University of Pharmacy, Kharkiv
  • Yu. V. Levachkova National University of Pharmacy, Kharkiv
  • V. M. Chushenko National University of Pharmacy, Kharkiv
  • S. M. Pushok National University of Pharmacy, Kharkiv
Keywords: vaginal candidosis, pessaries, antibacterial activity, fluconazole, amaranth oil


Today the problem of treatment of vaginal candidosis and creation of effective drugs for the treatment of this disease is actual for modern gynecology and pharmacy.

Vaginal candidosis is a variety of fungal infection that is cause  by microscopic  fungi of Candida, which are conditionally pathogenic. These fungi are the part of the normal human microflora, but in adverse conditions begin to proliferate.

Treatment of vaginal candidosis is the etiological and includes applying local antifungal medicines. Ukrainsan pharmaceutical market is represented by drugs of synthetic substances which have considerable side effects and a high level of resistance. Drags based on natural substances are practically absent.

The objective of the work was experimental study of antibacterial activity combined vaginal pessaries for the treatment of vaginal candidosis.

Models of new extemporaneous pessaries containing fluconazole and amaranth oil were the object of the study. The traditional method «diffusion in the agar» was used in the work. Microbiological studies were conducted on the basis of the

Mechnikov Institute under the supervision of candidate of biological sciences Osolodchenko T. P. The diffusion of the drug in agar was carried by the «wells» metod. Statistical processing of results was carried out in accordance with the requirements the State Pharmacopoeia of Ukraine.

It is established that pessaries exhibit a pronounced antimicrobic properties and do not concede on the known activity of the drug fluconazole, entitled «Fusys». The proposed composition of the pessaries allows to obtain the drug with significant antimicrobial and antifungal effects and satisfactory physical and chemical characteristics.


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How to Cite
Yarnykh, T. G., Levachkova, Y. V., Chushenko, V. M., & Pushok, S. M. (2018). Study of antibacterial activity of combined vaginal pessaries with fluconazole and amaranth oil. Farmatsevtychnyi Zhurnal, (2), 60-64. Retrieved from
Pharmaceutical technology

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