Studing conditions of sildenafil extraction by organic solvents

  • L.I. Osypchuk -
  • I.J. Halkevich -
Keywords: sildenafil, photocolorymetric determination, conditions of extraction

Abstract

The dependence of sildenafil extraction efficiency from pH value and nature of organic solvents was studied. Maximal amounts of this preparation are extracted by 1,2-dichlorethane at pH 6,0—8,0.

The influence of electrolytes on sildenafil extraction efficiency was studied. Electrolytes solution of natrium chloride (5% and 25 %) and solution of ammonium sulfate (5 %, 25 % and 50 %) decrees extraction efficiency of this preparation.

The extraction-photometric method of quantitative determination of sildenafil was developed. This method is based on formation of complex with bromocresol green in buffer at pH 4,5. The limit of determination of this method is 8 mg in 15 ml of sample volume. Relative error of this method is ± 1,05 %.

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Published
2008-02-20
How to Cite
Osypchuk, L., & Halkevich, I. (2008). Studing conditions of sildenafil extraction by organic solvents. Farmatsevtychnyi Zhurnal, (1), 83-87. Retrieved from https://pharmj.org.ua/index.php/journal/article/view/1228
Section
Original Articles