Synthesis, physico-chemical and pharmacological properties of anilides of 3,5-dibrom-N-phenylanthranylic acids
Two possible methods of reception of anilides of 3,5-dibromsubstituens of N-phenylanthranylic acids are investigated. There have been given NMP-, IR-spectrum and chromatographic characteristics of obtained compounds and analgetic, antifungal, anti-inflammatory and diuretic activity have been studied. The structure-activity analysis has been carried out among the compounds under research and some regularities of such dependence have been revealed. According to classification by K.K. Sydorov, synthesized compounds at their intrastomach enterig belong to low toxic compounds (DL50= 1200—2500 mg/kg).
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