Synthesis, physico-chemical and pharmacological properties of anilides of 3,5-dibrom-N-phenylanthranylic acids
Abstract
Two possible methods of reception of anilides of 3,5-dibromsubstituens of N-phenylanthranylic acids are investigated. There have been given NMP-, IR-spectrum and chromatographic characteristics of obtained compounds and analgetic, antifungal, anti-inflammatory and diuretic activity have been studied. The structure-activity analysis has been carried out among the compounds under research and some regularities of such dependence have been revealed. According to classification by K.K. Sydorov, synthesized compounds at their intrastomach enterig belong to low toxic compounds (DL50= 1200—2500 mg/kg).
References
Bryzitsky OA Synthesis, physicochemical properties, reactivity and biological activity of derivatives of nitrobenzoic and amino- and nitro-N-phenylanthranilic acids: Abstract. dis. ... cand. pharmacy. Science. - X., 2005. - 20 p.
Brun LV Reparative properties of glucosamine and its derivatives: Abstract. dis. ... cand. biol. Science. - K., 2004. - 21 p.
Danilenko VC, Chernoshtan KO, Kuzteiko 1.J. and others. // Scientific bases of drug development: Proceedings of the scientific session of the Department of Chemistry of the National Academy of Sciences of Ukraine. - X .: Osnova, 1998. - S. 230-240.
Preclinical studies of drugs: Method, recommendations. / Ed. Corresponding Member AMS of Ukraine OV Stefanova. - К .: Авиценна, 2001. - 528 с.
Isaev SG // Medicines for humans. - X., 2000. - T. 12, № 1. - S. 54—58.
Isayev SG, Bryzitsky OA, Svechnikova OM // Med. Chemistry - 2003. - Vol. 5, № 4. - P. 104—107.
Isasv SG, Zupanets IA, Pavliy OO etc. // Visn. pharmacy. - 2001. - № 3 (27). - P. 44-45.
Isayev SG, Pavliy OO, Zupanets IA etc. Optimization of the search for effective drugs based on N-phenylanthranilic acids: Information. sheet № 153—2003. - K., 2003. - Vip. № 13 on the problem of "Pharmacy" - 3 p.
Isayev SG, Sorokina IO, Pavliy OI etc. // Current issues of pharmacy. and honey. science and practice. - Zaporozhye, 2006. - Issue 15. 15. - Vol. 1. - P. 30—33.
Isayev SG, Sorokina IO, Svechnikova OM etc. // Med. chemistry. - 2006. - V. 8, № 4. - P. 27-30.
Isaev SG, Tkach AA, Zupanets IA Prospects for the search for new low-toxic compounds in a number of nitro derivatives of phenylanthranilic acid and glucosamine, Dep. In GNTB of Ukraine 01/09/97. - № 30. - Ук-97. - 12 p.
Isayev SG, Chikina OL, Zhegunova GP // Medical chemistry. - 2004. - T. 6, № 4. - S. 13—17.
Pavliy OO, Isayev SG, Chikina OL etc. // Medicines. - 2006. - № 3/4. - S. 62—65.
Pavliy OO, Kobzar NP, Isayev SG etc. // Pharmac. magazine. - 2006. - № 3. - S. 68—73.
Pat. 33114А Ukraine. The method of obtaining substituted 3-, 4-, 5-, 6-nitro-2-N-phenylanthranilic acids / SG Isayev, OI Pavliy, IA Zupanets and others. (Ukraine). - Publ. 19.02.2001, Bull. № 1. - 3 p.
Pat. 56772 And Ukraine. 4-Chloro-N- (2'-carboxyphenyl) anthranilic acid, which has anti-inflammatory, analgesic activity. / SG Isayev, IA Zupanets, LV Brun and others. (Ukraine). - Publ. 15.05.03, Bull. №5.-4 p.
Yartseva LV, Svechnikova OM, Isayev SG etc. // Med. chemistry. - 2003. - T. 5, № 4. - S. 90—93
Choulga IS, Issaev SG The antipaludiqes of synthesis. - Kharkov, 1994. - 20 p.
This work is licensed under a Creative Commons Attribution 4.0 International License.
