Synthesis and studying of antituberculosis activity of 5-arylidene-3-(benzothizol-2-ylamino)-2-thюхо-4- thiazolidones
Abstract
Following reaction of 2-hydrazinobenzthiazole and thiocarbonyl-bis-thioglicolic acid 3-(benzothiazol- 2-ylamino)-2-thioxo-4-thiazolidone was synthesized as starting compound for obtaining of new 5-ary- lidenederivatives in Knoevenagel condensation with aromatic aldehydes. Synthesized compounds displayed hydrazine-hydrazono tautomerism, which confirmed by NMR spectra. Antituberculosis activity screening allowed us to identify 5-phenylpropenylidene- and 5-(4-tret-butylphenylmethylidene)-3-(benzothiazol- 2-ylamino)-2-thioxo-4-thiazolidones as «hit-compounds», which are treated as a platform for novel directions for the purposeful synthesis of new molecules with «drug-like» properties.
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