Research antiamnesic activity of the new combined preparations

  • L.V. Jakovleva -
  • О.J. Mishchenko -
Keywords: antiamnesic activity, experimental retrograde and anterograde amnesia, combined prepa¬rations: «Phepolenum», «Pollentarum», «Phelentarum» nootropic preparation «Piracetamum»

Abstract

The estimation antiamnesic activity of the new combined preparations created from products of beekeeping and succinic acid: «Phepolenum», «Pollentarum» and «Phelentarum», on influence on preservation of conditional reaction passive avoiding of rats in conditions of experimental retrograde and anterograde amnesia is lead. The received results testify about expressed antiamnesic activity of the new combined preparations containing succinic acid: «Pollentarum» and «Phelentarum». Antiamnesic effect of these preparations is comparative and superior the effect of nootropic preparation «Piracetamum». Pollentarum’s and phelentarum’s antiamnesic activity supplements their investigated pharmacodinamic properties and it enables to characterize preparations as adaptogenes. Phepolenum does not have antiamnesic activity.

References

Belenichev IF, Gancheva OV // Pathology. - 2004. - T. 1, № 1. - S. 4—14.

Belenichev IF, Gubsky YI, Pavlov SV et al. // Modern problems of toxicology. - 2005. - № 3. - P. 4-20.

Belenichev IF, Stets VR, Mazur IA // Experimental physiology and biochemistry. - 2002. - № 1. - P. 7-11.

Bobkov Yu.G., Vinogradov VM, Katkov VF etc. Pharmacological correction of fatigue. - М .: Медицина, 1984. - 207 с.

Dunaev VV, Belenichev IF, Gubsky YI et al. // Modern problems of toxicology. - 2004. - № 1. - P. 7-14.

Mishchenko O.Ya., Yakovleva LV // Medical chemistry. - 2004. - Vol. 6, №.4. - S. 28—32.

Seifulla RD, Ordzhonikidze ZG etc. Drugs and dietary supplements in sports: A practical guide for sports doctors, coaches and athletes. - М .: Литтера, 2003. - 320 с.

Fedorov VN Pharmacodynamics of adaptogens: experimental and clinical research: Author's abstract. dis. ... Dr. Med. Science. - M., 1999. - 47 p.

Bures J., Buresova O., Huston J.P. Techniques and basic experiments for the stady of brain and behavior.— N.Y .: Elsevier science publishers B.V., 1993. - 399 p.

Floyd R. // P.S.E.B.M. - 2002. - Vol. 222, № 2. - P. 236-267.

Voronina T. // Neurosci. Lett. - 2000. - Vol. 312, № 34. ó P. 456ó463.

Published
2008-04-24
How to Cite
Jakovleva, L., & MishchenkoО. (2008). Research antiamnesic activity of the new combined preparations. Farmatsevtychnyi Zhurnal, (2), 108-112. Retrieved from https://pharmj.org.ua/index.php/journal/article/view/1189
Section
Original Articles