The validation of the photocolorimetric quantitative determination method for the riboflavin solutions of the drugstore preparation
Abstract
In the article is brought statistical motivated procedure of the validation of the photocolorimetric quantitative determination method of the riboflavin in the intra-drugstore storage (water solution of the riboflavin 0,02 %). The validation of the analytical methods held at scheme, which is specified in SPU; the following parameters were considered: range of application, specificity, linearity, exactness, accuracy, robustness, convergence of the results, intra-laboratory exactness, that has allowed to define the ability of the methods to solve the delivered problems.
References
Belikov VG, Stepanyuk SN // Pharmacy. - 1988. - №2. - S. 39—41.
Grizodub AI // Pharmacom. - 2002. - № 3. - S. 42—50.
Grizodub AI, Leontiev DA, Denisenko HV and dp. // Ibid. - 2004. - № 3. - S. 3—17.
State Pharmacopoeia of Ukraine. - X .: RIREG, 2001. - 556 p.
State Pharmacopoeia of Ukraine: Supplement. 1.— X .: РІРЕГ, 2004. - 494 с.
Evtifeeva OA, Georgiyants VA // Pharmacom. - 2007. - № 1. - S. 69—81.
Kuleshova MI, Guseva LN, Savitskaya OK Analysis of dosage forms manufactured in pharmacies. - М .: Медицина, 1989. - 288 с.
Order of the Ministry of Health of Ukraine № 626 of 15.12.2004 (with changes and additions). "On approval of the Rules of production (manufacture) of drugs in a pharmacy" // Legal aspects of pharmacy. - X., 2006. - T. 3. - S. 49—59.
Terno IS, Tikhonov AI. Grizodub AI and dp. // Pharmacom. - 2005. - № 2/3. - S. 104—115.
Charles O. Wilson, Ole Gisvold, Robert F. Doerge. Textbook of Organic Medicinal and Pharmaceutical Chemistry, - London, 1977. - 425 p.
European Pharmacopoeia. 5th ed. - Electronic version. - 2779 p.
Richard S. Rivlin. Riboflavin. - New York and London: Plenium Press, 1996. - 211 p.
This work is licensed under a Creative Commons Attribution 4.0 International License.
