Fast method for detection and quatitative determination of barbituric acid derivatives

  • L.V. Gudzenko -
  • R.P. Pantaler -
  • А.В. Blank -
Keywords: diphenylcarbazone, chromasurol S, barbiturates, Triton X-100, dimethylformamide

Abstract

The system Cu(ІІ)-diphenylcarbazon-chromazurol S-barbiturate and its possibility for analyti­cal using was studied. The drop express test allowing to detect up to 88 micrograms of barbiturates in 1 mg of the sample is proposed. Optimal conditions for kinetic spectrophotometric determination of barbiturates are found. At determination of 0,1—0,5 mg of phénobarbital relative standard deviations amount 0,18—0,08.

References

Харкевич Д.А. Pharmacology: Textbook. allowance. - М .: Медицина, 1999. - 345 с.

Bondar VS, Mamina OO, Karpushina SA etc. Toxicological chemistry. Lecture notes. - X .: Golden Pages, 2002. - 160 p.

Oros G.Yu., Selemenev VF, Krisilova EV and dp. // Sorption and chromatographic processes. - 2006. - V. 6, № 2. - P. 277-283.

State Pharmacopoeia of Ukraine. - X .: RIREG, 2001. - 556 p.

Zolotov Yu.A., Ivanov VM, Amelin VG Chemical test methods of analysis. - M .: Editorial URSS, 2002. - 304 p.

Podchaynova VN Simonova LN Copper (Analytical chemistry of elements). - М .: Наука, 1990. - 279 с.

Ostrovskaya VM, Zaporozhets OA, Budnikov GK etc. Water. Indicator systems. - М .: ЭКОНИКС, 2002. - 265 с.

Yongnian Ni, Chao Liu., Kokot S. // Anal. Chim. Acta. - 2000. - Vol. 419, № 2. - P. 185-196.

Published
2008-08-26
How to Cite
Gudzenko, L., Pantaler, R., & BlankА. (2008). Fast method for detection and quatitative determination of barbituric acid derivatives. Farmatsevtychnyi Zhurnal, (4), 87-91. Retrieved from https://pharmj.org.ua/index.php/journal/article/view/1127
Section
Original Articles