Identification of β -cyclodextrin inclusion complex by infrared spectroscopy
Fast and reliable identification of obtaining product is very important in the industrial technology of synthesis of pharmaceutical substances.
Objective - to study inclusion complexes of β-cyclodextrin with α-bromizovalerian acid and β-cyclodextrin with mint oil by applying near infrared spectroscopy absorption. Compare the spectra obtained with the spectra of equimolar mechanical mixture of the respective components.
Β-cyclodextrin complexes with α-bromizovalerian acid and β-cyclodextrin with mint oil were prepared at a well-known technique. Mechanical mixture of β-cyclodextrin with α-bromizovalerian acid and β-cyclodextrin with mint oil were obtained by mixing the components in a molar ratio of 1:1.
This paper shows the possibility using method of absorption near-infrared spectroscopy for rapid identification β-cyclodextrin inclusion complexes, as an example used complexes of β-cyclodextrin with α-bromizovalerian acid and β-cyclodextrin with peppermint oil. By comparing the spectra obtained inclusion complexes with the spectra of equimolar mechanical mixture of the corresponding components proved reliability the identification of the target product and the ability to distinguish between an inclusion complex and the mechanical mixture of the components. It is shown that the near infrared spectra obtained using an instrument Thermo Nicolet IS50, Thermo Scientific, inclusion complexes of β-cyclodextrin with a different guest molecules are different from each other.
2. Al-Marzouqi A. H., Shehatta I., Jobe B., Towanda A. Phase solubility and inclusion complex of itrconazole with β-cyclodextrin using supercritical carbon dioxide // J. Pharmac. Sci - 2006. - N 95. - P. 292-304.
3. Rowe R. C., Sheskey P. J., Owen C. C. Handbook of Pharmaceutical Excipients. - London: Publication Division of the Royal Pharmaceutical Society of Great Britain, 2006.
4. Loftsson T., Brewster M. E. Loftsson T. Pharmaceutical applications of cyclodextrins: basic science and product development // J. Pharmacy and Pharmacol. - 2010. - N 62. - P. 1607-1621.
5. Loftsson T., Stefansson E. Cyclodextrins in ocular drug delivery: theoretical basis with dexamethasone as a sample drug // J. Drug Del. Sci Tech - 2007. - N. 17. - P. 3-9.
6. Lim H. J., Cho E. C., Shim J. et al. Polymer-associated liposomes as a novel delivery system for cyclodextrin bound drugs // J. Colloid. Interface Sci. - 2008. - N 2. - P. 460-468.
This work is licensed under a Creative Commons Attribution 4.0 International License.