Synthesis, structure and biological activity of 2-(N'-R-iliden)-gidrazino-3,5-dibrombezoic acid
Abstract
The synthesis of 2-(N'-R-iliden)gidrazino-3,5-dibrombenzoic acid has been carried out. The composition of 7 synthesized compounds was proved by the data of element, and IR-, NMR- spectra. The purity was controlled by the method of thin- layer chromatography. It was established, that the synthesized substances have bacteriostatic and fungistatic activity. According to classification by K.K. Sydorov synthesized compounds their intrastomach entering belongs to low toxic compounds (DL50=1000—1800 mg/kg). These investigations to prospects of search of biologically active substances among the given chemical compounds.
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