Stadies at the development of farmaceutical composition of the combined drug of Diklokain
The scientific substantiation of pharmaceutical composition of Diklokin — injection drug based on diclofenac sodium and lidocaine hydrochloride is presented. Optimum pH ranges of solution taking into account presence of active ingredients and the solvent system that allow to increase solubility of sligthly soluble diclofenac sodium and to prevent it hydrolysis to the insoluble acid form have been chosen. The choice of stabilizers that allows to get stable preparation during the regulated term of storage has been grounded.
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