Purposeful synthesis, antimycobacterial activity and acute toxicity of new derivatives of isonicotinic and picolinic acids
Abstract
Purposeful synthesis of new derivatives of isonicotinic and picolinic acids on the basis of computer predictionhas been worked out. Structure of synthesized compounds confirmed by NMR-spectroscopy and elemental analysis. Antimycobacterial activity and acute toxicity have been studied. All synthesized compounds possessed high level of antimycobacterial activity. Cyclopentylidenehydrazide of isonicotinic acid have been selected, which possessed activity comparable with isoniazide and lower acute toxicity in vivo.
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