Study on the composition of fatty and organic acids of the feverfew herb (Tanacetum Parthenium (L.) Schultz Bip.)
Abstract
In recent years, herbal medicines have become increasingly popular for the treatment of many diseases because they have a complex and multifactorial influence on the body. Fatty and organic acids are important groups of biologically active substances for the improvement of many pathological human’s conditions. Feverfew (Tanacetum parthenium (L.) Schultz Bip.) is a promising source of biologically active substances with many years of success in medicine and insufficiently studied chemical composition. The analysis of fatty and organic acids is one of the directions of our comprehensive study of the feverfew herb grown in Ukraine.
The aim of the work was to conduct a study of the qualitative composition and quantitative content of fatty and organic acids in the feverfew herb grown in Ukraine.
For the study, we used the feverfew herb, which was grown in the scientific fields of the Botanical Garden of the National University of Ukraine (2019). The studies were carried out by a gas chromatography-mass spectrometric method on an Agilent Technologies 6890N chromatograph with a 5973 mass spectrometric detector.
35 carboxylic acids were found and identified in the samples. Among them 21 acids are saturated, 5 are unsaturated and 9 are aromatic. The total content of carboxylic acids in feverfew herb was 26.54 mg/g. Among the identified fatty and organic acids in the feverfew herb the greatest amount of the following acids was observed: succinic (4.89 mg/g), levulinic (4.34 mg/g), citric (2.73 mg/g), palmitic (2.15 mg/g), linoleic (1.71 mg/g), oxalic (1.53 mg/g) and linolenic (1.07 mg/g) acids. Among the aromatic acids in the feverfew herb the dominant compounds were p-coumaric (2.4%), benzoic (1.89%) and ferulic (1.40%).
For the first time, a chromatography-mass spectrometric determination of the qualitative composition and quantitative content of organic and fatty acids in feverfew herb collected in Ukraine was carried out. The data obtained indicate a varied composition and rich content of acids in domestic raw materials and will be used to create medicines based on the feverfew herb.
References
Mousa H. A. Health Effects of Alkaline Diet and Water, Reduction of Digestive-tract Bacterial Load, and Earthing // Altern Ther Health Med. –2016 – N 1. – P. 24–33.
Hayaloglu A. A., Demir N. Physicochemical characteristics, antioxidant activity, organic acid and sugar contents of 12 sweet cherry (Prunus avium L.) cultivars grown in Turkey // J. Food Sci. – 2015. – V. 80, N 3. – P. 564–570. https://doi.org/10.1111/1750-3841.12781
Carr A. C., Maggini S. Vitamin C and Immune Function // Nutrients. – 2017. – V. 9, N 11. – P. 1211–1217. https://doi.org/10.3390/nu9111211
Mills E., O'Neill L. A. Succinate: a metabolic signal in inflammation // Trends Cell Biol. – 2014. – V. 24, N 5. – P. 313–320. https://doi.org/10.1016/j.tcb.2013.11.008
Simopoulos A. P. An Increase in the Omega-6/Omega-3 Fatty Acid Ratio Increases the Risk for Obesity // Nutrients. – 2016. – V. 8, N 3. – P. 128–135. https://doi.org/10.3390/nu8030128
Pareek A., Suthar M., Rathore G. S., Bansal V. Feverfew (Tanacetum parthenium L.): A systematic review // Pharmacognosy Reviews. – 2011. – N 5 (9). – P. 103–110. https://dx.doi.org/10.4103%2F0973-7847.79105
Mohsenzadeh F., Chehregani A., Amiri H. Chemical composition, antibacterial activity and cytotoxicity of essential oils of Tanacetum parthenium in different developmental stages // Pharm. Biol. – 2011. – V. 49, Iss. 9. – P. 920–926. https://doi.org/10.3109/13880209.2011.556650
Rezaei F., Jamei R., Heidari R. Evaluation of the Phytochemical and Antioxidant Potential of Aerial Parts of Iranian Tanacetum parthenium // Pharm. Sci. – 2017. – V. 23, N 2. – P. 136–142. https://doi.org/10.15171/PS.2017.20
WHO guidelines on good agricultural and collection practices (GACP) for medicinal plants // World Health Organization Geneva. – 2003. – 72 р. https://www.who.int/medicines/publications/traditional/gacp2004/en/
Krivoruchko E., Kanaan H., Samoilova V., Ilyina T., Koshovyi O. Carboxylic acids from brown algae Fucus vesiculosus and Padina pavonica // Ceska a Slovenska Farmacie. – 2017. – V. 66, N 5. – P. 287–289.
Derzhavna farmakopeia Ukrainy / DP «Ukrainskyi naukovyi farmakopeinyi tsentr yakosti likarskykh zasobiv». 2-he vyd. – Kharkiv: DP «Ukrainskyi naukovyi farmakopeinyi tsentr yakosti likarskykh zasobiv». – 2015. – T. 1. – 1110 s.
Zarubina I. V., Lukk M. V., Shabanov P. D. Antihypoxic and antioxidant effects of exogenous succinic acid and aminothiol succinate-containing antihypoxants // Bull. Exp. Biol. Med. – 2012. – V. 153, N 3. – P. 336–339. https://doi.org/10.1007/s10517-012-1709-5
Hawkins S. G. Antimicrobial Activity of Cinnamic Acid, Citric Acid, Cinnamaldehyde, and Levulinic Acid Against Foodborne Pathogens / University of Tennessee Honors Thesis Projects. – 2014. – 10 p.
Ishutina N. A. Antyokyslytelnaia aktyvnost oleynovoi kyslotы u beremennыkh s herpes-vyrusnoi ynfektsyei // Biulletn VSNTs SO RAMN. – 2013. – № 1 (89). – S. 25–28.
Anwar A., Abdalla S. O., Aslam Z. et al. Oleic acid-conjugated silver nanoparticles as efficient antiamoebic agent against Acanthamoeba castellanii // Parasitol. Res. – 2019. – V. 118, N 7. – P. 2295–2304. https://doi.org/10.1007/s00436-019-06329-3
Adamczak A., Ożarowski M., Karpiński T. M. Antibacterial Activity of Some Flavonoids and Organic Acids Widely Distributed in Plants // J. Clin. Med. – 2019. – V. 9, N 1. – P. 109–115. https://doi.org/10.3390/jcm9010109
Abbasi-Parizad P., De Nisi P., Adani F. et al. Antioxidant and Anti-Inflammatory Activities of the Crude Extracts of Raw and Fermented Tomato Pomace and Their Correlations with Aglycate-Polyphenols // Antioxidants (Basel). – 2020. – V. 9, N 2. – P. 179–185. https://doi.org/10.3390/antiox9020179
Kronenberger T., Ferreira G. M., Ferreira de Souza A. D. et al. Design, synthesis and biological activity of novel substituted 3-benzoic acid derivatives as MtDHFR inhibitors // Bioorg. Med. Chem. – 2020. – V. 28, N 15. – 30 p. https://doi.org/10.1016/j.bmc.2020.115600
This work is licensed under a Creative Commons Attribution 4.0 International License.
