Synthesis and preliminary evaluation of pharmacological potential of rhodanine deivatives with benzothizole moiety in molecules
Abstract
Following reaction of (2-oxobenzothiazol-3-yl)acetic acid hydrazide and thiocarbonyl-bis-thioglic- olic acid N-(4-oxo-2-thioxo-4-thiazolidin-3-yl)-2-(2-oxobenzothiazol-3-yl)acetamide was synthesized as starting compound for obtaining of new 5-ylidenederivatives in Knoevenagel condensation with aromatic aldehydes and isatine derivatives. Structure of synthesized compounds was confirmed by 1H NMR spectra. Anticancer, antituberculosis and antiviral activity screening allowed us to identify some «hit-compounds», which are treated as a platform for novel directions for the purposeful synthesis of new molecules with «drug-like» properties.
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