Study of physicochemical and biologycal properties ilydenhydrazides of 2-(5-R-4-Rl-l,2,4-triazol-3-thio)-acetic acids
A new 2-(5-R-4-R1-1,2,4-triazol-3-thio)-acetic acids were synthesized. For this compounds the reduction reaction were studied. The structures of the synthesized compounds were confirmed by the elemental analysis, IR, 1H-NMR spectra and their individuality by the thin layer chromatography method. A few 2-(5-R1-4-R2-l,2,4-triazol-3-thio)-acetic acids tested for antibacterial effects. We have established the regularities between the structure of the receiving compounds and their antimicrobial activity indicators.
Kazitsyna LA, Kupletskaya NB Application of UV, IR and NMR spectroscopy in organic chemistry. - M,: Higher. 1971, 264 p.
Kaplaushenko AG // Zaporozhye. honey. . - 2007. - No. 1/2007 (40). - P. 104-107.
Kaplaushenko AG, Knish EG, Panasenko OI // Pharmacist. . - 2007. - Vol. 1, No.1. - P. 32-35.
Kaplaushenko AG Synthesis, physicochemical and biological properties of S-derivatives of 5- (2-, 3-, 4-nitrophenyl) -1,2,4-triazole-3-thione: Dis. Cand. farm. of sciences. - K., 2006. - 201 p.
Knysh E.G. Synthesis, physicochemical and biological properties of N- and S substituted 1,2,4-triazoles: Dis. Dr. Pharmacist. of sciences. - X., 1987. - 350 p.
Panasenko O.I. Synthesis, transformation, physico-chemical and biological properties of amino and thio derivatives of 1,2,4-triazole: Dis. Dr. Pharmacist. of sciences. - K., 2005. - 412 p.
VV Parchenko Synthesis, physicochemical and biological properties of 1,2,4-triazole-3-thione derivatives containing the furan nucleus: Dis. Cand. formats. of sciences. - K., 2006. - 207 p.
This work is licensed under a Creative Commons Attribution 4.0 International License.