Synthesis and pharmakological activity salts on the basis of substitued of 2-oxoindolin-l-acetas and 9-aminoacridini

  • S.G. Isaev -
  • A.O. Mayboroda -
  • V.V. Drugovina -
  • N.E. Sheveleva -
  • Z.G. Yeryomina -
  • A.P. Mylnikova -
Keywords: synthesis, salts of 9-aminoacridini, pharmacological activity

Abstract

With the purpose search optimization of compounds with antimicrobial activity on the basis salts of substituted of 9-aminoacridini and 2-oxoindolin-l-acetic acids the synthesis was carried out.

The structure of salts was confirmed by the data of the element analysis and IR-spectroscopy. Was fixed that 2-oxoindolin-l-acetas of 9-aminoacridin show bacteriostatic V and rise activity of sodium salt benzylpenicllin in subbacteriostatic concentration. Salt of 9-aminoacridin on classification by K.K. Sidorov concern to a class of mini-toxical substances.

References

Bolotov VV, Kovaleva SV, Stepanenko VI etc. // Physiologically active substances. - 1999. - № 1 (27). - P. 51-54.

Bolotov VV, Kovaleva SV, Stepanenko VI etc. // Bulletin of Pharmacy. - 1998. - № 17. - P. 15-18.

Voliansky YL, Krestetska SL // Medical chemistry. - 2002. - Vol. 4, No. 3. - P. 92-98.

Preclinical drug studies: Method. Recommendations / Ed. Corresponding Member Academy of Medical Sciences of Ukraine OV Stefanov. - K .: Avicenna, 2001. - 528 p.

Isaev SG // Pharmacist. . - 1999. - № 3. - P. 52—54.

Isaev SG // Medication. - 2001. - № 3/4. - P. 72-74.

Isaev SG // Topical issues of pharmaceutical science and practice: Coll. wash. - Zaporizhzhia, 2004. - Issue. 12, Vol.2. - P. 35-38.

Kobzar NP, Isaev SG, Shevelyova N.Yu. etc. // Pharmacist. . - 2005. - № 5. - P. 76-80.

The method of using 5-nitro-9-aminoacridinium benzoates as microadditives to enhance the specific activity of the benzylpenicillin sodium salt: Inform. letter No. 61-98 / Ex. SG Isayev, VD Yaremenko, AA Tkach in dr. - K., 1998. - Iss. № 7. (on the problem of "pharmacy") - 2 p.

Pat. 48073 Ukraine, IPC SO7D 219/10, A61K 31/435. N-Acetylantranilates 2-ethoxy-6,9-diaminoacridinium exhibiting antimicrobial activity / SG Isayev, NO Volkova, IA Zapanets and others. (Ukraine). - № 1697390, 4766603. - Publ. 08/15/02, Bul. № 8.

Pat. 48078 Ukraine, IPC SO7D 219/10, A61K 31/435. 2-Ethoxy-6,9-diaminoacridinium 2-chloro-4-nitrobenzoate, which exhibits bacteriostatic activity / SG Isayev, NO Volkova, SM Drovoz and others. (Ukraine). - № 17115185, 4824485. - Publ. 08/15/02, Bul. № 8.

Pat. 48069 Ukraine, IPC SO7D 219/10, A61K 31/435. 2-Ethoxy-6,9-diaminoacridinium 2-chloro-3,5-dinitrobenzoate, which exhibits antimicrobial and anti-inflammatory activity / SG Isayev, NO Volkova, IL Diky and others. (Ukraine). - № 1633777,4730936. - Publ 15.08.02, Bul. № 8.

Published
2009-04-28
How to Cite
Isaev, S., Mayboroda, A., Drugovina, V., Sheveleva, N., Yeryomina, Z., & Mylnikova, A. (2009). Synthesis and pharmakological activity salts on the basis of substitued of 2-oxoindolin-l-acetas and 9-aminoacridini. Farmatsevtychnyi Zhurnal, (2), 71-75. Retrieved from https://pharmj.org.ua/index.php/journal/article/view/1007
Section
Original Articles

Most read articles by the same author(s)